Quinolones immune response

HLA) of the major histocompatibility complex (MHC) on chromosome 6 remains an active area of investigation, and one might expect further discoveries that help to distinguish at risk patients before administration of a potential harmful drug (see example of abacavir below). As so often seen in immune responses, previous exposure to drugs can also induce increased sensitivity and here the question of cross-reactivity needs to be kept in mind (see below). Note, however, as already pointed out, there are many examples of reactions occurring on first exposure as witnessed by reactions to cotrimoxazole, quinolones, muscle relax-ants, contrast media, and so on. 

Quinolones are an alternative. Results of in vitro susceptibility tests do not always correlate with clinical effect and treatment should not necessarily be altered in the light of such results. Duration of treatment (usually >9 months) depends particularly on the response and on the recovery of immunity after ART. 

---