Quinolone-fused oxepine

A single quinolone-fused oxepine 45 was reported in a study on the gold (I)-catalyzed formation of functionalized quinolones (130L4234).The starting 2-alkynylarylazide derivatives such as 44 undergo a 1,3-acetoxy shift, followed by cyclization of the azide and a ring-expansion via a 1,2-shift. 

A novel quinolone-ring fused oxepine 56 (n = 1), reported by Joseph et al., was accessed by a ring-closing metathesis reaction on the precursor 55, which was made in turn from 53 via 54, and a Claisen rearrangement on the last compound. An aza analogue of 56 (n = 1) was made in a similar direct approach <03SL2089>. 

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See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ , ]

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