4-Quinolinecarbohydroxamic acid

Short heating of 4-quinolinecarbohydroxamic acid (205) with formamide affwds 4-aminoquinoline (207) via the isocyanate (206), while use of a large excess of formamide and increasing the temperature slowly give N-(4-quinolyl)urea (208) exclusively, as shown in Scheme 32. Intermediacy of 0-formates or equivalents has been suggested in the above modification of the Lossen reaction. ... 

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