Quinoline ring, 1,2,3,4-tetrahydro- from

One final example that underscores the power of intramolecular domino reactions to achieve the stereoselective synthesis of complex nitrogen heterocycles comes from the work of Barluenga and Gonzalez, who studied the preparation of tetrahydro-quinolines by intramolecular arylation of olefins induced by the in-house developed IPy2BF4 iodonium reagent. When applied to amine 102, this method afforded the tetracyclic compound 103 by the creation of three rings and five stereocenters in an elegant, fully diastereoselective cationic cyclization cascade (Scheme 3.32) [79]. 

Ring Expansions, Contractions, and Rearrangements. l,3,4,5-Tetrahydro-henzo[f>]azepin-2-ones or 1,2,3,4-tetrahydro-henzo[d]azepin-2-ones are accessible from simple tribromomethyl-suhstituted A benzyl quinolines, or isoquinoline precursors via a AgNOs-promoted ring enlargement. The reaction was used for the synthesis of the antianginal zatebradine (eq 10). 

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