Quinoline 1-oxide, hydrogen-exchange

The most reactive position for base-catalyzed hydrogen exchange of the 1-oxide derivatives of quinoline and isoquinoline is the position adjacent to the heteroatom and nearest the fused benzene ring. Thus for isoquinoline 1-oxide the positionalreactivity is given by 1 > >3 > > 4,... 

Yamane et al.[13] determined cobalt in sea water and river waters with a catalytic spectrophotomeiric method after on-line preconcentration using a column packed with quinolin-8-ol immobilized on silica gel. The tartrate eluate from the preconcentraiion had to pass through a second column packed with a strongly acidic cation exchanger to remove iron(III) and manganese(II) which interfere in the catalytic reaction of oxidation of protocatechuic acid by hydrogen peroxide. An extremely low detection limit of 0.005 /ig 1 was obtained. However, the sampling frequency was less than 2 h . ... 

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