Quinoline drugs

Walash et al. [10] determined primaquine and other quinoline drugs in bulk and in pharmaceuticals by a titrimetric method. The method is based on reaction with l,3-dibromo-5,5-dimethylhydantoin or TV-bromosuccinimide as the titrant. Primaquine was determined either by usual titration or by potentiometric titration with the brominating agents. The recovery was approximately 100%. The method was simple, precise, and accurate. 

Fitch CD. Ferriprotoporphyrin IX, phospholipids, and the antimalarial actions of quinoline drugs. Life Sci. 2004 74 1957-1972. 

Chloroquine and hydroxychloroquine are quinoline drugs used for the chronic management of rheumatoid arthritis, discoid and systemic lupus erythematosus, and other collagen diseases. Because chloroquine is rapidly absorbed and becomes highly concentrated in various tissues due to melanin and protein binding, it is now used only for malaria prophylaxis. Hydroxychloroquine has replaced it primarily because of its superior safety profile. 

Graves, P.R., Kwiek, J.J., Fadden, P., et al. (2002) Discovery of novel targets of quinoline drugs in the human purine binding pro-teome. Mol. Pharmacol. 62, 1364-1372. 

Quinoline drug—heme interactions and imphcations for antimalarial cytostatic versus cytocidal activities 13JMC5231. 

This chapter deals with the synthesis of different quinoline derivatives and its biological activity. Brief history of quinoline drugs, synthesis with respect to active functional group at different position of quinoline core are also cover. 

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