Quinidine Opiates

Albumin, aminophylline, aspirin, heparin, insulin, metoclopramide, NSAIDs, muromonab-CD3 (OKT3), opiates, penicillins, propafenone, quinidine, senna, sulfonamide antimicrobials, and vancomycin... 

In a comparative study, 5 extensive metabolisers and 6 poor metabolisers of the cjTochrome P450 isoenzyme CYP2D6 were given hydroeodone, and another 4 extensive metabolisers of CYP2D6 were given hydrocodone after pre-treatment with quinidine. The metabolism of the hydroeodone to its active metabolite hydromorphone was found to be high in the extensive metabolisers who described good opiate effeets but poor in the poor metabolisers and the extensive metabolisers pre-treated with quinidine who described poor opiate effects . For the effeet of quinidine on hydromorphone metabolism, see Opioids -i- Quinidine , p.l83. 

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