Quinazolin-4-ones, 3-aryl-2-methyl condensation with

Some new facile syntheses for 2-methyl-3-(o-tolyl)quinazolin-4-one (methaqualone) " and 3-aryl-2-mercapto-quinazolin-4-ones have been announced. The former synthesis can be carried out in high yield in one pot by allowing isatoic anhydride to react sequentially with aniline in toluene and pentane-2,5-dione in ethanolic hydrogen chloride. The latter preparation consists of condensing aryl isothiocyanates with anthranilic acid in hot acetic acid-sodium acetate mixture. 

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