Quetiapine SSRIs

Initial case reports of risperidone s improvement in aggressive behavior, hyperarousal, and flashbacks has led to further investigation into the adjunctive use of atypical antipsychotics in refractory PTSD. Quetiapine (mean dose 100 mg/day range, 25 to 300 mg/ day) reduced core PTSD symptoms over a 6-week period when added to current therapy. Olanzapine (mean dose 15 mg/day) added ad-junctively to SSRIs decreased PTSD symptoms and significantly improved sleep compared with placebo. Patients gained an average of 13.2 pounds over the course of the 8-week trial. ... 

Haloperidol (Haldol), risperidone (Risperdal), loxapine (Loxitane), ziprasidone (Geodon), quetiapine (Seroquel), clozapine (Clozaril), aripiprazole (Abilify), and thioridazine (Mellaril) are targeted in this solid phase extraction (SPE), liquid chromatography— tandem mass spectrometry (LC-MS/MS) method. Both 9-hydroxy-risperidone (Paliperiodone), an equipotent metabolite, and mesoridazine (Serentil) are also included in this method as they are pharmacologically active major metabolites of risperidone and thioridazine, respectively (4). Olanzapine (Zyprexa) can be quantified with this instrument method however, the extraction method is a liquid-liquid basic extraction (see Note 1). Due to the subsequent administration of antidepressants in conjunction with antipsychot-ics, this method can also be used for many of the common antidepressants, including the selective serotonin reuptake inhibitors (SSRIs) (see Note 2). 

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