Quantitative biopharmaceutics classification system

Figure 6.16 The Quantitative Biopharmaceutics Classification System (QBCS) utilizes specific cutoff points for drug classification in the solubility-dose ratio (1/0), apparent permeability (Papp) plane. Each class of the QBCS can be characterized on the basis of the anticipated values for the fraction of dose absorbed, Fa and the fraction of dose dissolved, at the end of the dissolution process assuming no interplay between dissolution and uptake. In essence the classification system is static in nature.

$Figure 6.16 The Quantitative Biopharmaceutics Classification System (QBCS) utilizes specific cutoff points for drug classification in the solubility-dose ratio (1/0), apparent permeability (Papp) plane. Each class of the QBCS can be characterized on the basis of the anticipated values for the fraction of dose absorbed, Fa and the fraction of dose dissolved, at the end of the dissolution process assuming no interplay between dissolution and uptake. In essence the classification system is static in nature.$

Rinaki, E., Valsami, G., and Macheras, P., Quantitative biopharmaceutics classification system The central role of dose/solubility ratio, Pharmaceutical Research, Vol. 20, No. 12, 2003, pp. 1917-1925. [Pg.401]

Quantitative Structure-Property Relationship Analysis of Drugs Pharmacokinetics Within the Framework of Biopharmaceutics Classification System Using Simplex Representation of Molecular Structure... [Pg.461]

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