Quantifying control loop interactions

Interaction among control loops in a multivariable system has been the subject of much research over the last 20 years. Various types of decouplers were explored to separate the loops. Rosenbrock presented the inverse Nyquist array (INA) to quantify the amount of interaction. Bristol, Shinskey, and McAvoy developed the relative gain array (RGA) as an index of loop interaction... 

Olkkola KT, Tammisto T. Quantifying the interaction of rocuronium (Org 9426) with etomidate, fentanyl, midazolam, propofol, thiopental, and isoflurane using closed-loop feedback control of rocuronium infusion. Anesth Analg 1994 78(4) 691-6. 

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