Quality of solvents used in titrimetry

For titrimetric determinations performed in an aqueous medium it is highly recommended to use distilled water and to perform a blank determination if necessary. 

For determinations performed in non aqueous media, flic solvents should be as anhydrous as possible and, of course, inert to the titrant and the substance. Their purity should be such that they do not contain impurities which could react wifli the substance to be analyzed. A blank titration should be performed if necessary. 

Far from being inert and not affecting the molecules dissolved in it, flic solvent can affect the behavior ofthe solute in different ways. This chapter has aimed to support flic idea that it is important for the chemist and the pharmacist to control the quality of flic solvents used in the different areas of pharmaceutical activity. As we have tried to show, many pitfalls can be avoided during the developmentof a drug if a thorough investigation of flic quahty ofthe solvents used is carried out. 

Reichardt, Solvents and solvents effect in organic chemistry, 2nd editirai, 1998, 

Le bon usage des solvants. Information Toxicologique n° 3, Unite de prevention du risque 

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