Quality control immunohistochemistry controls

Sompuram SR, Kodela V, Zhang K, et al. A novel quality control slide for quantitative immunohistochemistry testing. J. Histochem. Cytochem. 2002 50 1425-1434. 

True LD. Quality control in molecular immunohistochemistry. Histochem. Cell. Biol. 2008 130 473-480. 

To ensure quality diagnosis, immunohistochemistry quality control will become even more important. It is expected that the next five years will see increased participation in proficiency testing, as an increase in the number of laboratories that become accredited. New technologies on the horizon will also likely facilitate more efficient means of quality control. 

The Clinical Laboratory Improvement Amendments (CLIA) set standards designed to improve the quality of all laboratory testing. In the first portion of this chapter, we discuss the CLIA requirements that apply to most Immunohistochemistry laboratories, and explain topics such as certification, test complexity, patient test management, proficiency testing, personnel, quality control, quality assurance, and compliance. 

Presently, immunohistochemistry requires improvements in quality, reproducibility, speed, quantitation, and standardization. Some of these goals can be achieved by using computerized bar code-driven automatic immunostainers that automatically dispense reagents, control washing, mixing, and heating to optimize immunohistochemical reaction... 

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