Qualitative analysis isotopic pattern

The hyphenation of CE with MS detectors certainly offers the best opportunities for the qualitative analysis of natural compounds in general and of tropane alkaloids in particular, which is evident from the increasing number of articles published in recent years. Methods applying CE-MS for analysis of tropane alkaloids have been developed mainly in clinical and forensic laboratories. With this respect, HRMS detectors, enabling the identification of a compound through accurate mass measurement and isotopic pattern, are preferred for combination with CE. A comprehensive overview of principles and applications performed by CE coupled to TOE/MS detection has been published by Staub et al. [110]. 

Modern scientific tools like the so-called odour-activity value (OAV) concept were developed to unravel the quantitative and qualitative pattern of individual chemicals. Quantitation is achieved in an extremely accurate way by means of isotope dilution analysis. 

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