QSAR models oral absorption

Yoshida F, Topliss JG (2000) QSAR Model for drug human oral bioavailability. J Med Chem 43 2575-2585 Zhao YH, Le J, Abraham MH et al. (2001) Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure-activity relationship (QSAR) with the Abraham descriptors. J Pharm Sci 90 749-784... 

Absorption, Distribution, Metabolism, and Elimination. All of the marketed sulfonyl-ureas are nearly completely absorbed, and the class has excellent oral bioavailability. A quantitative structure-activity relationship (QSAR) model for human drug oral bioavailability (84) has recently been developed, in which the descriptors A logD (logHe.s - log... 

Dorronsoro, I., Ghana, A., Abasolo, M.I., Castro, A., Gil, C., Stud, M. and Martinez, A. (2004) CODES/ neural network model a usefid tool for in silico prediction of oral absorption and blood—brain barrier permeability of structurally diverse drugs. QSAR Comb. Sci., 23, 89-98. 

The use of a faster-growing cell line, MDCK (Madin-Darby canine kidney) cells, appears to be a good replacement for Caco-2 cells (Irvine et al. 1999). The parallel artificial membrane permeation assay (PAMPA) is a rapid in vitro assay, in which transcellular permeation is evaluated (Kansy et al. 1998). PAMPA may also be used to predict oral absorption, blood-brain barrier penetration, and human skin permeability (Fujikawa et al. 2007) by using QSAR models. To our knowledge, neither PAMPA, Caco-2 cell monolayers nor MDCK cells have been used to examine the absorption/permeability of the pyrethroids. The advantages and limitations of the Caco-2 model were reviewed by Artursson et al. (1996) and Delie and Rubas (1997). 

In silico ADME modeling Predictive QSAR models for human intestinal absorption and oral bioavailability... 

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