Pyrrolo-l,5-benzothiazepines

As is the case with other five-membered rings condensed to 1,5-benzo-thiazepines, pyrrolo derivatives have received intensive study and several synthetic routes have appeared. Although it would be possible to obtain several pyrrolo-l,5-benzothiazepines, only two types of fusion have been reported. 

Some derivatives 14 showed marked sedative activity comparable or superior to that exhibited by diazepam (73FES494 80FES279). 

9) (81FES765). Compound 30 showed sedative activity similar to that of diazepam. 

Fusion of a heterocyclic ring having an oxygen atom onto the thiazepine nucleus can occur only at faces b and c. Three combinations are possible for each type of fusion, but only 3,4-b and 3,4-c are known. 

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