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Pyrrole natural products

The antitumor activity of dibromophakellstatin 41 has been measured in vitro in cancer cell lines the selectivity profile might indicate a new mechanism of action 07BMCL346 . [Pg.132]

The asymmetric allylic alkylation (AAA) reaction has been adapted for use with pyrrole nucleophiles <06JACS6054>. For example, treatment of pyrrole 55 and cyclopentene 56 with a palladium catalyst in the presence of a chiral additive gave pyrrole 57 in up to 92% ee. The latter was elaborated into piperazinone-pyrrole natural product, agelastatin A 94. [Pg.143]

PYRROLE NATURAL PRODUCTS AND MATERIALS 5.2.4.1 Natural Products and Biologically Active Small Molecules... [Pg.148]

Pyrrole Natural Products with Antitumor Properties... [Pg.66]

Keywords Pyrrole Natural products Antitumor agents Multi-drug resistance... [Pg.66]

Iwao and Ishibashi [37] have utilized their methodology depicted in Scheme 13 for the preparation of ningalin B hexamethyl ether (91) with compound 71 functioning as the key precursor for this relay synthesis. This strategy appears to be very flexible for a wide variety of pyrrole natural products. [Pg.89]

Gupton JT (2006) Pyrrole Natural Products with Antitumor Properties. 2 53-92... [Pg.260]

Gupta SP (2006) QSAR Studies on Calcium Channel Blockers. 4 249-287 Gupton JT (2006) Pyrrole Natural Products with Antitumor Properties. 2 53-92 Gute BD, see Basak SC (2006) 3 39-80... [Pg.304]

A ruthenium-catalyzed three-component reaction between propargylic alcohols, 1,3-dicarbonyl compounds, and primary amines leading to fully substituted pyrroles was developed <07CEJ9973>. Cyclohexa[a]pyrroles ( azabicyclo[4.3.0] systems ) were formed by a three-component sequence involving allenic ketones, primary amines, and acryloyl chloride <07SL431>. An oxidative dimerization sequence involving arylpyruvates in the presence of ammonia was the key step in an approach to the pyrrole natural product, lukianol A <07S608>. [Pg.127]

A palladium-mediated annulation of Y-( o-bromoary l)pyrroles across strained alkenes led to the formation of pyrrolo[l,2-a]quinolines <07OL1761>. An intramolecular Heck reaction involving tethered iodoarenes produced an entry to pyrrolo[2,3-t/][2]benzazepin-7-ones, analogues of the pyrrole natural product latonduines <07T867>. A Heck reaction of a 3-iodopyrrole with a 2,3-dihydrofuran provided pyrrole deoxyribonucleosides <07T12747>. [Pg.130]

This chapter is a review of reported work and we hope that it will be of assistance to scientists interested in pyrrole natural products. [Pg.67]

See other pages where Pyrrole natural products is mentioned: [Pg.143]    [Pg.146]    [Pg.148]    [Pg.148]    [Pg.148]    [Pg.149]    [Pg.127]    [Pg.68]    [Pg.103]    [Pg.514]    [Pg.128]    [Pg.128]    [Pg.129]    [Pg.132]    [Pg.132]    [Pg.132]    [Pg.132]    [Pg.133]    [Pg.128]    [Pg.143]    [Pg.146]    [Pg.148]    [Pg.148]    [Pg.148]    [Pg.148]    [Pg.149]    [Pg.160]    [Pg.160]    [Pg.117]    [Pg.117]    [Pg.118]   
See also in sourсe #XX -- [ Pg.53 ]



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