Pyrrole 3-ethoxycarbonyl-2,5-dimethyl-, ring

JCS(P1)621). The reaction of 1-ethoxycarbonylpyrrole with dimethyl 2,5-bis(diazo)-3,4-dioxoadipate also results in heteroarylation of the pyrrole ring to yield (100), which rearranges thermally to give dimethyl l-ethoxycarbonyl-4,6-dihydroxyindole-5,7-dicar-boxylate (76T269). 

Base-catalyzed de-O-acetylation and deesterification of the 3-(tetra-0-acetyl - d - arabino - tetritol -1 - yl) - 4 - ethoxycarbonyl - 2,5 - dimethyl - 2-nitropyr -role 1 took place with concomitant y-lactone ring formation to provide the furo[3,4-c]pyrrol-l-yl acyclo C-nucleoside 2 [85AQ(C)49] (Scheme 1). 

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