Pyrimidyls

Fluorination and iodination reactions are used relatively littie in dye synthesis. Fluorinated species include the trifluoromethyl group, which can be obtained from the trichi oromethyl group by the action of hydrogen fluoride or antimony pentafluoride, and various fluorotria2iQyl and pyrimidyl reactive systems for reactive dyes, eg, Cibacron F dyes. 

Phosphorothioate 0,0-DiethylO-2-Isopropyl-4-Methyl-6-Pyrimidyl Thiophosphate Diethyl 2-Isopropyl-4-Methyl 6-Pyrimidyl Thionophosphate Alpha-Tox Saralex Spectracide Cherrucal Formula C]2H2iNj03PS. 

Hydroxy group of rru -7,9u-H-7-(prepared from 7-formyl-2-(2-pyrimidyl)perhydropyrido[l,2-u]pyrazine by the treatment with MeOCH2P(Ph)3Cl in the presence of -Pr2NH in THF at 0°C, than with BuLi at room temperature (99MIP6). 

Die C=C-Doppelbindung der 2,4-Dioxo-5-[2-hydroxy-pyrimidyl-(4)]-l,2,3,4-tetra-hydro-pyrimidine und deren En-amin-Verbindungen wird durch Natriumboranat auch ohne Belichtung reduziert z.B.4 ... 

Alkylation of l-(2-pyrimidyl)piperazine (129) with 3-chloro-l-cyanopropane gives nitrile 130, which is reduced with LAH and then acylated with spiro-glutaric anhydride 131 to synthesize the tranquilizer buspirone (132).40... 

Figure 79 Assembly of a polyhedron achieved by complexation of l,3,5-tris(3,5-pyrimidyl)benzene with...

The 7-(2-oxoethyl) derivative was prepared from 7-formyl-2-(2-pyrimidyl)perhydropyrido[l,2- ]pyrazine by the treatment with MeOCHzP(Ph)3Cl in the presence of Pr 2NH in THF at 0°C, then with BuLi at room temperature < 1999WO99/020622>. Reaction of a 7-mesyloxymethyl group in perhydropyrido[l,2-tf Ipyrazine with NaCN in DMF at 110°C gave a 7-cyanomethyl derivative, which was converted into a 2-oxoethyl group by treatment first with DIBAL-H, then with 2M HC1. The 2-oxoethyl group was reacted with 4-FC6H4MgBr in THF at — 10°C to yield a... 

The self-assembly of di[4-(5-pyrimidyl)phenyl]dimethylsilane and -germane with (ethylenediamine)palladium dinitrate in an 1 2 ratio generated a new octahedral supramolecule containing group 14 elements <06ICC50>. 

While investigating the reaction of ZnPf2 with pyrimidine-5-carboxaldehyde 190, the Soai group made the important discovery that these two compounds reacted in the presence of a catalytic amount of (enantiomeric purity (as low as 2%) to furnish the same alcohol as the addition product with ee s up to 89% (Scheme 106). This most remarkable finding was the first case of asymmetric amplification in autocatalytic reactions.275... 

The antitrichomonal compound l-methyl-5-nitro-2-(2 -pyrimidyl)imida-zole (97 R = Me, R2 = pyrimid-2-yl) has been shown to be metabolized to the corresponding acetamide (118 R1 = Me, R2 = pyrimid-2-yl, R3 = Me) in both rats and humans (74JPS293). The acetamide (118 R1 = Me, R2 = pyrimid-2-yl, R3 = Me) was also produced synthetically by reduction of a solution of the nitroimidazole (97 R1 = Me, R2 = pyrimid-2-yl) in acetic acid with zinc powder and subsequent treatment of the aminoimidazole (96 R1 = Me, R2 = pyrimid-2-yl) in situ with acetic anhydride to give the acetamide (118 R = Me, R2 = pyrimid-2-yl, R3 = Me) (4%) (74JPS293). 

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