Pyrimidopyridine

The use of cerium trichloride for the Peterson alkenation has been q)plied by Ueda and cowoikers for nucleoside synthesis (Scheme S2). The anion was generated with LDA/cerium trichloride and condensed with the aldehyde (375). The product was treated with KH in THF and the pyrimidopyridine (377) isolated in S0% yield. 

Several routes to benzo[h]quinolines utilise other heterocyclic systems as the precursor. The fused pyrimidopyridine (66), obtained from 4-aminopyrimidine-5-carboxaldehyde and 1-tetralone, is readily l drolysed to 2-aminohenzo[h]quinoline-3-carboxaldehyde (67) (T. 

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