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Pyrimido indoles, synthesis

Some final examples of the Makosza indole synthesis are tabulated in Table 2. Volovenko and colleague report a simple synthesis of 3-substituted-2-amino-5-nitroindoles (entry 1), which were transformed into pyrimido[l,2-fl] indoles upon reaction with p-dicarbonyl compounds [26]. A conventional VNS method was used by Lerman and colleagues to craft 6- and 7-hydroxyindoles via sacrificial chlorine atoms that serve to increase the electrophilicity of the benzene ring toward cyanomethylation. Subsequent transfer hydrogenation (Pd/C/HCO NH ) gives the respective hydroxyindoles (entries 2, 3) [27], The preparation of 3,6-dimethyl-5-methoxyindole by Skibo and coworkers (entry 4) was the starting point in a synthesis... [Pg.359]

P. Tardieu, R. Dubest, J. Aubard, A. Kellmann, F. Tfibel, A. Samat, and R. Guglielmetti, Synthesis Mid photochromic characteristics of l,3-dihydrospiro[2fir-indole-2,3 -[3 /7]pyrimido[5,4-/7[l,4]benzoxa-zines] and 1,3-dihydrospiro[2/f-indole-2,7 -[7/f]thiazolo[5,4-/][l,4]benzoxazines], Helv. Chim. [Pg.107]

Myriad examples are known of oxindoles reacting to form indoles without prior carbonyl activation. Given (he vast scope of this subject, only a few early examples will be cited in addition to recent studies. Several groups have annulated oxindoles to access fused-indole heterocycles. Ila, Junjappa, and coworkers prepared pyrido[2,3-( ]indoles [61, 62] and 67/-indolo[2,3-fc]quinolines [63] using this approach (Scheme 9, equation 1). Adib and colleagues reported a simple synthesis of 9/7-pyrimido[4,5-Z ]indoles from oxindoles (eqnation 2) [64], and Bazgir and coworkers described a four-component one-pot a-carboUne synthesis... [Pg.563]


See other pages where Pyrimido indoles, synthesis is mentioned: [Pg.810]    [Pg.810]    [Pg.29]    [Pg.176]    [Pg.810]    [Pg.810]    [Pg.22]    [Pg.75]    [Pg.810]    [Pg.810]    [Pg.810]    [Pg.810]    [Pg.345]    [Pg.263]    [Pg.82]    [Pg.561]    [Pg.640]    [Pg.167]    [Pg.239]    [Pg.239]    [Pg.875]   
See also in sourсe #XX -- [ Pg.32 , Pg.69 ]




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