17/-Pyrimido diazepine-2,4-diones

Carboxy substituted diazepines 226 and 229 react with phenyl isocyanate to afford pyrimido diones 227 and 230, correspondingly (Scheme 48, Section 3.1.1.3 (1993JHC897)). N-Hydroxymethylation on an indole ring annulated to benzaze-pinone, as well as formation of the corresponding carbamate and urea, has been described (2004MI1076). 

Pyrimido(4,S-Jb [l,4]diazepin 4-one. 977 Pyrimido[l,2-6iind le. 1004 Pyrimido(l,2-aliiidole. 1329 I rimido[l,6-[Pg.778]

Cl3H12CIN3O2S, 7-Chloro-l,3,5-trimethyl-5H-pyrimido[5,4-b] 1,4)ben-zothiazine-2,4(1H,3H)-dione, 38B, 398 Cl3H12N2O2S, 5,6-Dihydro-6-(2-oxo-propyl)-4H-pyrrolo[1,2-a]thieno-[3,2-f][1,4-diazepine]-4-one, 45B, 380 Cl3H14N2O2S, 2-Amino-4,5-dihydro-7,8-dimethoxynaphtho[1,2-d]thia-zole, 43B, 483... 

---