Pyrimidinone-5-carboxylates, formation

The aminomethylenemalonates can be cyclized at high temperature as in the formation of pyrido[3,2-. With the aminomethylene-malonate group in the 4-/6-position in a free 2-pyrimidinone, cyclization is to the adjacent ring nitrogen <82JHC1581>. 

Cesium carbonate. 14, 77-78 15, 73-75 Alkylations. CS2CO3 has shown some O-alkylation of 2-pyrimidinone, diasterec alkylation/Wittig reaction to form ethoxyc Carbamates Formation and hydrotyn reaction with CO2 in the presence of Cs-jC alkylation. When the alkylating agent is a alkyl)oxazolidin-2-one is the product. Ap precedes A-carboxylation. 

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