Pyrimidinone acids

GEP2808070>. The reversed 5-chloro-4-acid chlorides give the corresponding pyrido[3,2-d]pyrimidinones. 

Pyrimidine-4(3H)-thione, 6-methoxy-5-nitro-reduction, 3, 88 Pyrimidinethiones acidic pK, 3, 60 S-acylation, 3, 95 N-alkylated synthesis, 3, 139 aminolysis, 3, 94 desulfurization, 3, 93 electrophilic reactions, 3, 69 hydrolysis, 3, 94 oxidation, 3, 94, 138 pyrimidinone synthesis from, 3, 133 reactions... 

Though the great majority of antiinflammatory agents contain some form of acidic proton, occasional compounds devoid of such a function do show that activity. Thus the nonacidic pyrazolylpyrimidine epi razole (47) is described as a nonsteroid antiinflammatory agent. Reaction of pyrimidinone 42 with phosphorus oxychloride leads to the chloro derivative Replacement of halogen with hydrazine gives... 

Chlorotrifluoroethylene was converted in one step using nBuLi to dieth-ylfluoromalonate, which was a useful precursor for 5-fluorouracil (84CL1573). Fluorinated pyrimidinones can also be obtained from a,fi-unsaturated carboxylic acid derivatives prepared from 1-phosphonyloxy-perfluoroalkyl-l-alkenephosphonates (86TL2879). 

C,4H]3N0 42771-78-8) see Flurbiprofen 2-acetylamino-6-chloro-5-nitro-4(31/)-pyrimidinone (C9HJCIN4O4 51471-45-5) see Abacavir iV-acetyl-4-amino-2,4-dideoxy-2,3-didehydroneuraminic acid... 

Diacetylcyclopropane reacts with 3-amino-l, 2,4-triazole in acetic acid (either aqueous or glacial) to give triazolopyrimidines 28 <%1ZV1322>, whilst a selection of fiised-ring pyrimidines, for example the l,2,3-triazolo[4,S-prepared using amino hetmoarenecarboxamides and esters <96H(42)691 >. 

Ci0HuN4O6 H20 4-Amino-l-(4-amino-4-deoxy-/ -D-glucopyranosyl-uronic acid)-2( 1 H)-pyrimidinone, monohydrate (GOUGERIO)200... 

Rappaport HP (1988) The 6-thioguanine/5-methyl-2-pyrimidinone base pair. Nucl Acids Res 16(15) 7253-7267... 

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