Pyrimidine-diones

Ethyl-5-phenyl-2,4,6(l//,3//,5//)-pyrimidinetrione synonym 5-ethyl-5-phenylbarbituric acid. 5-Ethyl-1-methyl-5-phenylbarbituric acid. 5-Ethyl-5-phenyldihydro-2-thioxo-4,6(lEf,5H)-pyrimidine-dione synonym 5-ethyl-5-phenyl-2-thiobarbituric acid. 5-Ethyl-5-hexyl-2-thiobarbituric acid. 5-Ethyl-5-isopentylbarbituric acid. 5-Ethyl-5-(l-methylbutyl)-2-thiobarbituric acid. 5-(l-Cyclo-hexen-l-yl)-l,5-dimethylbarbituric acid. 5-Ethyl-5-(l-methylbutyl)barbituric acid. 5-(l-Cyclohexen-l-yl)-5-ethylbarbituric acid. [Pg.223]

CmllijCINjOf, 75843-06-0) see Sorivudine 1 -P-l)-arabinofuranosyl-S-ethenyl-2,4( lH,3//)-pyrimidine-dione... [Pg.2300]

Applications of MCR-Derived Heterocycles in Drug Discovery Table 6 Antibacterial activities of select pyrazolo-pyrido-pyrimidine-diones... [Pg.249]

Bazgir A, Khanaposhtani MM, Soorki AA (2008) One-pot synthesis and antibacterial activities of pyrazolo[4, 3 5, 6]pyrido[2, 3-] d pyrimidine-dione derivatives. Bioorg Med Chem Lett 18 5800-5803... [Pg.284]

Chloro-l,3-dimethyluracil undergoes 1,2-Addition to benzene on irradiation. A 1,3-addition path has been discounted. Other studies by the same group have demonstrated that the irradiation of the pyrimidine dione derivative (140) in acidic media (a large excess of trifluoroacetic acid) brings about its conversion into the tricyclic product (141). ... [Pg.90]

The ring protons of the pyrimidinones and pyrimidine diones would... [Pg.265]

Isothiazolo[5,4-d]pyrimidine3. - Heating the isothiazole semi-carbazide (68 R=NHNH5), prepared from (68 R=OEt) + N-H., with aqueous NaOH yields the isothiazolo[5,4-d]pyrimidine dione (69)°. ... [Pg.161]

Sodium 5-allyl-5-(l-methylbutyl)-2-thiobarbiturate 4, 6-(lH, 5H)-Pyrimidine-dione, dihydro-5-(l-methylbutyl)-5-(2-propenyl)-2-thioxo-, monosodium salt U.S.P.,... [Pg.115]

Dioxo-5-diazopyrimidine 5-Diazo-3,4-dioxo-pyrimidine DU 5-Diazo-2,4(1H, 3H)-pyrimidine-dione. [Pg.139]

Bis-0-(tett-butyldimethylsilyl)-fS-D-ribofuranosylJ thymine ]-3 -spiro-5 -(4"-amino-l", 2"-oxathiole-2, 2 -dioxide ). l-[ 4-Amino-9-[ [(I, I-dimethylethyl) di-methylsilylJoxy ]-6-[[ [(1,1 -dimethy-lethyl) dimethylsilyl]oxy [methyl[-2,2-dioxido-1,7-dioxa-2-thiaspiro [4.4 ]non-3-en-8-yl]-5-methyl-2,4( 1H,3H) -pyrimidine-dione, 9 Cl [141781-17-1]... [Pg.948]

Pyridones were accessed from coupling of a diyne with an isocyanate. This reaction was tolerant of three-component couplings to generate either 2-pyridones or pyrimidine-diones, depending on the alkyne employed and concentration of the isocyanate (Figure 13.35) [80,81]. [Pg.411]

Figure 4 Biosynthesis of riboflavin in yeasts (6) GTP (7) 5-amino-6-ribitylamino-2,4(i//,7//)pyrimidine dione (8) 3,4-dihydroxy-2-butanone 4-phosphate (9) 6,7-dimethyl-8-ribityllumazine (1) riboflavin.

Pyridones or Pyrimidine-diones from Diynes or Alkynes and Isocyanates... [Pg.299]

In a more detailed study, Duong and Louie showed that the combination of Ni and IPr is slightly more efficient than SIPr. More importantly, they also showed that the reaction outcome was strongly dependent on isocyanate concentration as well as on alkyne substitution. When isocyanate concentrations were high, pyrimidine-diones were produced in good yields from unsymme-trically hindered alkynes by a double insertion of isocyanates (Equation... [Pg.300]

The control of stoichiometry of reacting species is very important in the aforementioned protocols. If the isocyanate is used in excess, pyrimidin-dione products are formed instead of pyridones. For example, the reaction of TMS-methyl alkyne and 8 equiv of isocyanates yielded pyrimidin-dione 92 (Scheme 2.27) [23]. [Pg.53]

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