Pyridyl methylsulfinyl benzimidazole

Recognition of the mechanism of acid secretion then led to the development of a new class of antiulcer drugs, the substituted pyridyl methylsulfinyl benzimidazoles, one of which is shown in the figure above. These are now the mainstay for treatment of most add related diseases. Both the sodium pump and the acid pump remain specific drug targets, digoxin for the former, proton pump inhibitors for the latter. 

The structure of four examples of these drugs is given in the illustration. It can be seen that they all share the same backbone, a 2-pyridyl methylsulfinyl benzimidazole with various substitutions on the pyridine or benzimidazole moieties, which are added to modify solution reactivity or to decrease toxicity. 

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