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Pyridoxal phosphate-dependent enzymes mechanism-based inactivation

The pyridoxal phosphate-dependent enzymes have been a major focal point in the development of mechanism-based inactivators. Pyridoxal phosphate (PLP) is utilized in resonance stabilization of carbanions at the a- and /3-carbons of amino acids in a variety of reactions which lead to chemical transformations at the a-, /3-, and y-carbons of the substrate (Walsh, 1979). These carbanion equivalents... [Pg.221]

Because L-vinylglycine also irreversibly inactivates ACC synthase in a time-dependent manner when the enzyme is incubated with L-vinylglycine and pyridoxal phosphate in the absence of AdoMet and because ACC synthase, like other pyridoxal-dependent enzymes, may catalyse p.-y-elimination of AdoMet to produce L-vinylglycine, it has been proposed that the mechanism-based inactivation proceeds through the formation of a vinylglycine-enzyme complex which is inactive (Fig. 3). Detailed kinetic studies indicate that the... [Pg.218]


See other pages where Pyridoxal phosphate-dependent enzymes mechanism-based inactivation is mentioned: [Pg.323]    [Pg.323]    [Pg.93]    [Pg.219]    [Pg.323]    [Pg.450]    [Pg.88]    [Pg.621]    [Pg.889]   
See also in sourсe #XX -- [ Pg.221 , Pg.222 , Pg.223 , Pg.224 , Pg.225 , Pg.226 , Pg.227 , Pg.228 ]




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Dependence mechanism

Enzyme dependent

Enzyme inactivators

Enzyme mechanism

Enzymes inactivation

Mechanics Dependency

Mechanism-based enzyme inactivation

Mechanism-based inactivation

Mechanism-based inactivator

Mechanism-based inactivators

Pyridoxal enzymes

Pyridoxal phosphat

Pyridoxal phosphate

Pyridoxal phosphate enzyme

Pyridoxal-dependent enzymes

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