Pyridopyrimidinones structure

Figure 6.15 Co-crystal structure of PF-04691502 bound to PI3K-y. The ring nitrogen of the pyridopyrimidinone forms the common H-bond hinge region interaction with the backbone NH of Val-882, while the exocyclic amine forms an additional interaction with the Val-882 backbone carbonyl. The pyridine nitrogen binds to Tyr-867 and Asp-841 through a conserved water molecule.

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