Pyridoacridine type alkaloids

In 1983, Schmitz et al. reported the isolation and structure elucidation of a second example (calliactine 364, isolated in 1940, was the first) of a pyridoacridine type alkaloid called amphimedine (297) 134). It is a fused... 

Alkaloids that possess quinolinequinone and quinolinequinoneimine units (1) have been classified in the literature as members of the aza-anthraquinone, diaza-anthraquinone, quinolinequinone, pyridoacridine, and pyrroloquinolinequinoneimine type alkaloids, although they all have common subunits (1), quinolinequinone and quinolinequinoneimine. Most of the alkaloids isolated in recent years with such units fall into the pyrido-... 

As representative of the derivatives of pyridoacridine, eilatin, a marine alkaloid inhibits in vitro cell proliferation in chronic myeloid leukemia patients [244], Other members of the pyridoacridines, such as alkaloids isolated from a Cystodytes sp. ascidian, inhibit topoisomerase II [245], Additionally, analogues derivatives of these type of alkaloids showed interesting anti-HIV activity [246],... 

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