Pyrido benzimidazole anxiolytics

Structure-activity relationships of anxiolytic pyrido-benzimidazoles 184... 

STRUCTURE-ACTIVITY RELATIONSHIPS OF ANXIOLYTIC PYRIDO-BENZIMIDAZOLES... 

NOVEL ANXIOLYTIC PYRIDO[ 1,2-u]BENZIMIDAZOLES WHICH INTERACT AT THE BZD SITE OF THE GABAa RECEPTOR 181... 

Advances in the molecular biology and pharmacology of the neurotransmitter, GABA, have established there is considerable heterogeneity in GA-BAa receptors, the receptors known to be modulated by all the clinically effective benzodiazepine anxiolytics. The consequent surge of activity to find anxiolytic agents which are more selective and possess fewer side-effects than the early benzodiazepines has led to the synthesis of a variety of novel structures. One such series of pyrido[l,2-a]benzimidazoles is described in Chapter 4. 

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