Pyrido azepine base

Finally Ebersbach s group succeeded in synthesizing the first (and, up to now, only known) authentic pyrido[l,2-a]azepine base 315 (Scheme 70) from their lactam 290 by thionation with Lawesson reagent (LR), methylation of thiolactam 313, and deprotonation of sulfenium salt 314 (91HCA1095). 

This review is based on Mosby s book cited above and covers the literature through 2009 together with several articles published in 2010. It includes pyrido[l,2-fl]azepines and their hydro products as well as linearly or angularly fused benzo and dibenzo derivatives. Patents are taken into account provided they reveal important aspects of synthesis or application. 

---