Pyridines, sulfonamido

To benzo[A]quinolinyl palladium(II) pyridine-sulfonamido complex (12.8 mg, 0.0200 mmol) in acetonitrile-c/i (0.6 mL) at 23 °C was added l-chloromethyl-4-fluoro-l,4-diazoniabicyclo [2.2.2]octane bis(tetrafluoroborate) (7.1 mg, 0.020 mmol). After stirring for 10 min at 23 °C, the colorless suspension formed a dark purple solution. The complex was characterized by nuclear magnetic resonance (NMR spectroscopy) in acetonitrile solution without purification. ... 

Into a solution of 15.9 grams of 3-amino-2-phenyl-pvrazole in 60 cc of anhydrous pyridine, 29 grams of p-carbethoxyamino-benzene sulfonyl chloride are introduced within about 25 minutes. When the reaction subsides, heating is carried out for a further hour to 90° to 95°C internal temperature. The reaction solution is then poured into 300 cc of 2 N hydrochloric acid. The precipitate is filtered with suction and recrystallized from dilute alcohol. The 3-(p-carbethoxyaminobenzene sulfonamido)-2-phenyl-pvrazole is obtained thus in white crystals of MP 175° to 176°C. 

The 3-sulfonamido-4-(3-methylbenzyl)amino-pyridine crystallized in the form of beige coloured cristals having a melting point of 184°-186°C. 

Carbinolamides (derived from keto amides) afford 2-sulfonamido-substituted furans when treated with Tf20 and pyridine (eq 61). ... 

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