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Pyridazine, 4-amino-, base-catalyzed

The base-catalyzed cyclization of ethyl 3-[alkyl(4-cyanopyridazin-3-yl)amino]propanoates gives ethyl 8-alkyl-5-amino-7,8-dihydropyridazine-6-carboxylates 1, which by acidic hydrolysis were converted to the corresponding ends 2. Due to their air sensitivity, ends 2 are partly converted into ethyl 8-alkyl-5-oxo-5,8-dihydiopyiido[2,3-c]pyridazine-6-carboxylates 3. To avoid mixtures, the oxidation is completed by treatment with tetrachloro-l,2-benzoquinone (o-chloranil).20... [Pg.9]

Hydrazone 1042 (prepared from 2-amino-l,l,l-trifluoro-3-phenylsulfonyl-2-propanol) is one more NNCC binucleophile for the synthesis of chain-fluorinated pyridazines (Scheme 222) [626], In this case, two-step reaction of 1042 with a-diketones is used, including acid-catalyzed hydrazone formation and base-... [Pg.477]


See other pages where Pyridazine, 4-amino-, base-catalyzed is mentioned: [Pg.196]    [Pg.251]    [Pg.362]    [Pg.74]    [Pg.362]    [Pg.580]    [Pg.139]   


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