Pyrid indoles

Z-aminO 1 -methy 1 6 phenylimidazo [4,5-b]-pyridine 2 aminO 3,7,8 trimethylimidazo[4,5 f]quinoxaline 2 aminO 3,4,7,8 tetramethyl 3H imidazO [4,5 f]quinoxaline inoxaline 3 aminO l,4 dimethyl SH pyrid [4,3 b] indole (Trp P I) and 3 aminO l methyl 5H pyrido [4,3 b]indole induced mutagenesis. Metabolic activation was required for positive results b... 

Ring expansion during Reimer-Tiemann reaction conditions on pyrroles and indoles to furnish pyrid-ines and quinolines was observed by Ciamician in 1881 (equations 13 and 14). Although a preparative reaction of little use due to the low yield, this transformation stimulated others to carry out ring expansion attempts on nonphenolic substrates with considerable success. ... 

Matcha and Antonchick prepared a series of indoles, pyrazoles, and pyrid-azinones via the functionalization of alkenes in a cascade multicomponent process. An electrophilic trifluoromethyl radical added to the terminal position of olefin 119 to give radical intermediate 121. Then, in a Fischer indolization-like process, phenylhydrazone 122, through an ene-hydrazine, cyclized to aminoindoline 123. After elimination of ammonia, indole 120 was isolated in good yield (14AG(I)11960). 

Methylene blue irradiation 9H-Pyrid[3,4-b]indoles from 3-j -aminoindoles... 

Skeletal rearrangement of cyclic Mannich bases l,2,3,4-Tetrahydro>5H-pyrid[4,3-b]indoles from l,2,3,4-tetrahydropyrimido[l,6-a]indoles... 

Benzoyl diloride added dropwise at -15° to 2-methylindole in pyridine, allowed to warm slowly to room temp., and stirring continued 3 days with passage of oxygen or oxygen-air 2-methyl-3-(pyrid-4-yl)indole. Y 67%. F. e. s. H. Deubel et al., B. 104, 705 (1971). 

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