Pyrazolones and related compounds

It is convenient to divide the anti-inflammatory pyrazolones into two groups pyrazol-5-ones XXVII), typified by amidopyrine, and pyrazolidine-3,5-diones XXVIII), of which the principal member is phenylbutazone. [Pg.82]

The best known members of this group are phenazone (antipyrine, [Pg.82]

Propylphenazone (XXVIl, R = CHMe2) has an analgesic potency similar to that of amidopyrine but its anti-inflammatory activity is reported to be less than half . [Pg.83]

5-one (Tarugan, XXIX) is reported to have 2—3 times the analgesic activity of amidopyrine and twice its activity in dextran oedema of the rat-paw . [Pg.83]

By incorporating nicotinamide into the side chain at C4 a potent analgesic drug with reduced toxicity was obtained (Nifenazone, Nicopyron, [Pg.83]

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