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Pyrazines Vilsmeier-Haack reaction

Ring closure y to a heteroatom is also a rather uncommon [5 + 1] procedure although there are some important exceptions. The most widely investigated is the Bernthsen acridine synthesis in which a diarylamine is condensed with a carboxylic acid in the presence of a Lewis acid (equation 73). More recently, it has been shown that acylanilines react with the Vilsmeier-Haack reagent to give quinolines in good yield (e.g. equation 74) and the mechanism of the reaction has been elucidated. A final example of [5 +1] ring closure y to a heteroatom which is of occasional use is the pyrazine synthesis outlined in equation (75). [Pg.78]


See other pages where Pyrazines Vilsmeier-Haack reaction is mentioned: [Pg.291]    [Pg.291]   
See also in sourсe #XX -- [ Pg.2 , Pg.789 ]

See also in sourсe #XX -- [ Pg.789 ]

See also in sourсe #XX -- [ Pg.789 ]

See also in sourсe #XX -- [ Pg.2 , Pg.789 ]

See also in sourсe #XX -- [ Pg.789 ]




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Haack

Haack Reaction

Pyrazine reactions

Pyrazines reactions

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Vilsmeier-Haack

Vilsmeier-Haack reaction

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