PYRAZINE, ALKYLPYRAZINES, AND ARYLPYRAZINES

This chapter covers the preparations, physical properties, and reactions of pyrazine and its C-alkyl, C-aryl, A-alkyl, or A-aryl derivatives as well as their respective di-, tetra-, and hexahydro derivatives (the last usually known as piperazines). In addition, it includes methods for introducing alkyl or aryl groups (substituted or otherwise) into pyrazines and hydropyrazines already bearing substituents and the reactions specific to the alkyl or aryl groups in such products. For simplicity, the term alkylpyrazine in this chapter is intended to include alkyl-, alkenyl-, alkynyl-, cycloalkyl-, and aralkylpyrazines likewise, the term arylpyrazine includes both aryl- and heteroarylpyrazines. 

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