Pyranmycin synthesized

Pyranmycin which contains both D-pyranose and L-pyranose at ring III, has been synthesized (Scheme 4.16). The p-glycosidic bond between rings II and... 

Pyranmycin which contains various D-pyranoses and L-pyranoses on ring III have been synthesized (Scheme 1). (73,14) The 3-glycosidic bond between... 

Table I. Minimum Inhibitory Concentration and Binding Scores of the Synthesized Pyranmycins ...

The constructed N-1 modified pyranmycin was assayed against aminoglycoside susceptible and resistant strains of Escherichia coli using ribostamycin, and butirosin as the controls. From the MIC values, the synthesized aminoglycoside with the attachment of AHB group at N-1 regain the activity against both resistant strains of bacteria (Table III). 

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