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Pyramid, Camps

FIGURE 26-8 Immunohistochemical localization of cAMP response element-binding protein (CREB) in rat hippocampal neurons. Using a polyclonal antibody which recognizes both CREB and phospho-CREB protein, it is apparent that CREB protein is enriched in the nucleus of pyramidal cells of the CA1 region of the hippocampus. Scale bar is 30 pm. (Courtesy of Dr Stephen Ginsberg, Department of Pathology, University of Pennsylvania.)... [Pg.467]

Huag T, Storm JF (2000) Protein kinase A mediates the modulation of the slow Ca2+-dependent K+ current, lsAHP,by the neuropeptides CRF, VIP, and CGRP in hippocampal pyramidal neurons. J Neurophysiol 83 2071-2079 Huang Y, Li X-C, Kandel ER (1994) cAMP contributes to mossy fiber LTP by initiating both a covalently mediated early phase and macromolecular synthesis-dependent late phase. Cell 79 69-79... [Pg.330]

Helmut Haas and colleagues showed that, in hippocampal pyramidal neurons, H2-receptor stimulation potentiates excitatory signals by decreasing a Ca2+-activated K+ conductance, presumably via cAMP production [11], H2-receptor activation depolarizes thalamic relay neurons slightly, increasing markedly apparent membrane conductance, a response due to enhancement of the hyperpolarization-activated cation current lh [20],... [Pg.2]

HT4 Receptor-Mediated Depolarization of CA1 Pyramidal Cells Activation of 5-HT4 receptors depolarizes pyramidal cells of the CA1 region of the hippocampus (45,46) through a mechanism that involves cAMP but is... [Pg.488]


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See also in sourсe #XX -- [ Pg.89 ]




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