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Purine template-based inhibitors

Purine Template-Based Inhibitors AP23464, AP23848, AP23846, AP23994,... [Pg.383]

Biosynthesis and function of RNA - Mcmy inhibitors of RNA synthesis, such as aotinomycin, act by complexing with DNA and inhibiting its template function in the biosynthesis of RNA.3 Base analogs, such as 6-mercapto-purine and 8-azaguanine, interfere with interconversions of ribonucleotide subunits and inhibit novo synthesis of RNA.3 Utilization of these biochemical pathways for the design of chemotherapeutic agents is limited by considerations similar to those discussed for inhibitors of DNA synthesis. [Pg.220]

See other pages where Purine template-based inhibitors is mentioned: [Pg.398]    [Pg.398]    [Pg.423]    [Pg.590]    [Pg.381]    [Pg.57]   
See also in sourсe #XX -- [ Pg.397 ]



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Purine bases

Template-based inhibitors

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