Psychostimulant drugs experiments

Historically, Saletu (1976) performed a series of EP experiments in health subjects to stud the action of several antipsychotics, antidepressants, anxiolytics and psychostimulants. Similar to Fink and Itil for the pharmaco-EEG, he reported on systematic, drug-type-related changes in EP latencies after somatosensoiy stimulation of his subjects. 

Paradoxical effects cognitive impairment and perseverative behavior are occasionally seen in children treated with psychostimulants. According to Greenhill et al. (1999) such phenomena are indicative of a drug overdose and will improve at dose reduction. Constriction of attention or overfocusing as a consequence of treatment with psychostimulants has been another critical issue (Breggin, 1999). Based on an extensive review of the literature and their own experience, Wilens and Biederman (1992) assert that there is no evidence of such phenomena at doses up to 1.0 mg/kg of methylphenidate. 

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