Psychosis modafinil

Modafinil is contraindicated in patients with a known hypersensitivity to it, and the drug should be used cautiously in patients with a history of psychosis or cardiovascular disease. 

There was exacerbation of psychosis in five of 83 patients with schizophrenia who took modafinil compared with two of 70 who took placebo [83 ]. 

There have been other reports of modafinil-associated psychosis in patients with narcolepsy [85, 86, 87 ]. 

A 21-year-old male with a history of depression was diagnosed with psychosis, which were probably due to selfadministration of high doses of modafinil over a period of 16 months (from 400 to 1600 mg/d) [42 ]. 

Rudhran V, Manjunatha N, John JP. High-dose, self-administered modafinil-related psychosis is it the pedal in the prodrome of psychosis J Clin Psychopharmacol 2013 33 576-7. 

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See also in sourсe #XX -- [ ]

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