Pseudoephedrine Aluminium hydroxide

Kaolin does not appear to interact significantly with pseudoephedrine, but aluminium hydroxide may possibly cause a more rapid onset of action. 

In a single-dose crossover study in 6 healthy subjects, 30 inL of aluminium hydroxide gel did not affect the total amount of pseudoephedrine absorbed from a single 60-mg dose over 24 hours, but the rate of absorption was significantly increased during the first 3 hours. Conversely, 30 rriL of a 30% suspension of kaolin redueed the amount of pseudoephedrine absorbed from a single 60-mg dose by just 10%. The rate of absorption was also decreased. ... 

The increased rate of absorption of pseudoephedrine seen with aluminium hydroxide is probably also due to pH rises, which favour the formation of the lipid-soluble absorbable form of pseudoephedrine. The reduced absorption with kaolin is probably due to adsorption of the pseudoephedrine onto the surface of the kaolin. 

Aluminium hydroxide may possibly cause a more rapid onset of pseudoephedrine activity (but this needs confirmation). Any interaction seems unlikely to be clinically significant. Similarly, the effects of kaolin on absorption are small and unlikely to be clinically important. For the effect of sodium bicarbonate on pseudoephedrine and ephedrine, see urinary alka-Iinisers%(p.l277). 

Lucarotti RL, Colaizzi JL, Baity H, Poust RI. Enhanced pseudoephedrine abscq>tion by cc -current administration of aluminium hydroxide 1 in humans. JPha/m Sci (1972) 61,903-5. 

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See also in sourсe #XX -- [ ]

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