Pseudodistoma arborescens

Chbani, M. Pals, M. Delauneux, J.M. Debitus, C. (1993) Brominated indole alkaloids from the marine tunicate Pseudodistoma arborescens. J. Nat. Prod., 56,99-104. 

Finally, it might be noted that several brominated tetrahydro- and dihydro-p-carbolines are known, for example woodinine (64) [52,53] and 19-bromoisoeudisto-min U (65) [54], both from Eudistoma spp. The tunicate Pseudodistoma arborescens has yielded arboresddine A (66) a brominated derivative of the well-known indolo[2,3-a]quinolizidine alkaloid ring system [55]. 

Arborescidines are alkaloids of P-carboline and show certain analogies with eudistomins. They have all been isolated from the species Pseudodistoma arborescens harvested in Northern New Caledonia. Only arborescidine D is cytotoxic in vitro to KB cells, with ID50 of 3pgml (Chbani et al., 1993). 

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