Proton acids on azole anions acidity of azoles

6 Proton acids on azole anions acidity of azoles 

The following data show the NH-acidity (water, significantly increases the acidity  

Ring substituents can have a considerable effect on the acidity of the system. In the 1,2,4-triazole series a 3-amino group decreases the acidity to 11.1, a 3-methyl group to 10.7, whereas a 3-phenyl group increases the acidity to 9.6, and 3,5-dichloro substitution to 5.2 (71PMH(3)l). 

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Orientation in azole rings containing three or four heteroatoms Effect of azole ring structure and of substituents Proton acids on neutral azoles basicity of azoles Proton acids on azole anions acidity of azoles Metal ions... 

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