Proteolysis and Peptide Mapping of IDPs

An additional challenge with conventional peptide-based HX-MS with disordered proteins is the amino acid sequence itself. Among the hallmarks of IDPs are a lack of sequence complexity and a low frequency of residues with hydrophobic side chains [3, 15]. Pepsin, although somewhat 

4 Identifying Disordered Regions with Hydrogen Exchange Mass Spectrometry 

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