Proteins tunneling pathways

Winkler JR. Electron tunneling pathways in proteins. Curr Opin Chem Biol 2000 4 192-8. 

This type of analysis enables one to find the optimal tunnelling pathways within a particular protein.155... 

Beth, J.N., Beratan, J.N., and Onuchic, J.N. (1992) Mapping electron tunneling pathways an algorithm that finds the minimum length Vmaximum coupling pathway between electron donors and acceptors in proteins, J. Am. Chem. Soc. 114, 4043-4046. 

Beratan, D. N., Nelson Onuchic, J., Winkler, J. R., and Gray, H. B., 1992, Electron-tunneling pathways in proteins. Science 258 1740nl741. 

Lin J, Balabin lA, Beratan DN. The nature of aqueous tunneling pathways between electron-transfer proteins. Science 2005 310 1311-1313. 

The prefactor, P, depends on the electronic coupling of donor and acceptor with the bridging orbitals. A correlation between p (cf. Eq. 3) and Ec (Eq. 4) is easily demonstrated An individual strand of a p-sheet protein defines a linear tunneling pathway along the peptide, spanning a distance (r — ro) of 0.34 nm per residue (three covalent bonds). Thus, inserting a p value of 10 nm in Eq. 3, the decay factor, Ec of Eq. 4 becomes 0.6 per covalent bond. 

EJectron-tunneling pathway for myoglobin modified at His-48, The pathway moves along the protein backbone from His-48 to Arg-45, and then to the heme via an H-bond (=) to the heme propionate. The His-48 to heme edge-edge distance is 12.7 A. ... 

Experimental evidence supports the tunneling-pathway prediction that different protein secondary structures mediate electronic couplings with different... 

---