Proteins, pulmonary delivery spray freeze drying

Custom-made SFD towers and apparatuses have been designed, built and improved to produce nearly monodisperse, low-density lyophilisate powders suitable for pulmonary dmg delivery. Spray-freeze-dried particles were characterized regarding their mean geometric particle size, aerodynamic behaviour, surface morphology and interior structure, API (protein) stabihty, powder flowability and reconstitution characteristics. 

---