Proteins phylogenetic profiling

Pellegrini, M., Marcotte, E. M., Thompson, M. J., Eisenberg, D., and Yeates, T. O. (1999). Assigning protein functions by comparative genome analysis Protein phylogenetic profiles. Proc. Natl. Acad. Sci. USA 96, 4285-4288. 

Pellegrini, M., E.M. Marcotte, M.J. Thompson, D. Eisenberg, and T.O. Yeates, Assigning protein functions by comparative genome analysis protein phylogenetic profiles. Proc Natl Acad Sci USA, 1999. 96(8) 4285-8. 

Acad. Sci. V.S.A., 96, 4285 (1999). Assigning Protein Functions by Comparative Genome Analysis Protein Phylogenetic Profiles. 

Figure 6.1. Phylogenetic profile method. Four genomes are shown, each containing a subset of proteins (PI, .P7). The presence or absence of a protein is given by 1 or 0 in the phylogenetic profile shown at lower left. Identical profiles are shown clustered on the right. In this example, the P2 and P7 are functionally linked because they exhibit the same phylogenetic profile. The P3 and P6 protein are similarly linked. Figure adapted from Pellegrini et al. (1999).

A phylogenetic profile is a description of the presence or absence of a particular protein in a set of organisms whose genome has been sequenced. The profile is a string with n entries, each one bit, where n is the number of... 

Marcotte, E. M., I. Xenarios, A. M. van der Bliek, and D. Eisenberg. Localizing proteins in the cell from their phylogenetic profiles. Proc Natl Acad Sci USA 97 12115-20. 

Protein Pathways 1999 Los Angeles, CA Phylogenetic profiling, domain analysis, expression profiling www.proteinpath ways.com... 

Proteins ate the main catalysts, stractural elements, signaling messengers and molecular machines of biological tissues. Phylogenetic profile generation and two-hybrid screen methods ate the major techniques used to study protein-protein interactions. 

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