Proteinases inhibitor

Hansson, T., Aqvist, J. Estimation of binding free energies for HIV proteinase inhibitors by molecular dynamics simulations. Prot. Eng. 8 (1995) 1137-1144... 

Hansson T and J Aqvist 1995. Estimation of Binding Free Energies for HIV Proteinase Inhibitors b Molecular Dynamics Simulations. Protein Engineering 8 1137-1144. 

Protein acidulant Protein additives Protein ammo acids a-l-Proteinase inhibitor Protein-based mimetics Protein Ca [42617-41-4] Protein channels Protein chromatography Protein crystal growth... 

Factor VIII, immunoglobulin, and albumin are all held as protein precipitates, the first as cryoprecipitate and the others as the Cohn fractions FI + II + III (or FII + III) and FIV + V (or FV), respectively (Table 7, Fig. 2). Similarly, Fractions FIVj + FIV can provide an intermediate product for the preparation of antithrombin III and a-1-proteinase inhibitor. This abiUty to reduce plasma to a number of compact, stable, intermediate products, together with the bacteriacidal properties of cold-ethanol, are the principal reasons these methods are stiU used industrially. 

IV, a-l-proteinase inhibitor antithrombin III IgM ceruloplasmin a- and P-globutins a-tipoprotein albumin 5-10... 

Alpha-1-proteinase inhibitor and antithrombin III are used to treat people with hereditary deficiencies of these proteins. Both can be recovered from Cohn Fraction IV (Table 7) using ion-exchange chromatography (52) and affinity chromatography (197), respectively. Some manufacturers recover antithrombin III directiy from the plasma stream by affinity adsorption (56,198,199). 

Affinity and specificity of proteinase inhibitors can be optimized by phage display... 

There are several additional plasmin inhibitors in the blood, e.g., a2-macroglobulin, ai-proteinase inhibitor, antithrombin, but their role in the control of fibrinolysis is questionable, because their action on plasmin is eliminated by fibrin. 

ACTH, adrenocorticotrophic hormone Met, methionine Met(O), methionine sulfoxide DTT, dithiothreitol L7, L12, Escherichia coli ribosomal proteins Met(0)-L12, L12 containing Met(O) residues a-l-PI, a-1-proteinase inhibitor Met(0)-a-l-PI, a-l-PI... 

Bishop et al. (1984) have isolated a pectic polysaccharide (6 kDa) from tomato leaves that can elicit the induction of proteinase inhibitors. Upon further hydrolysis this pectic polysaccharide yields oligogalacturanan (degree of polymerisation from 2 to 6) that still possesses the proteinase inhibitor inducing activities. 

Pixley R, Schapira M, Colman R The regulation of 63 human factor Xlla by plasma proteinase inhibitors. 

KROGDAHL A, HOLM H (1981) Soybean proteinase inhibitors and human proteolytic enzymes selective inactivation of inhibitors by treatment with human gastric juice. /M/fr. Ill 2045-51. 

SCHWARTZ J G, GUAN D, GREEN G M, PHILLIPS w T (1994) Treatment with an oral proteinase inhibitor slows gastric emptying and acutely reduces glucose and insulin levels after a liquid meal in type 11 diabetic patients. Diabetes Care. 17 255-62. 

Wong, P.S. and Travis, J. (1980). Isolation and properties of oxidised alpha-l-proteinase inhibitor from human rheumatoid synovial fluid. Biochem. Biophys. Res. Commun. 96, 1449-1454. 

Desrochers, P.E. and Weiss, S.J. (1988). Proteolytic inactivation of alpha-l-proteinase inhibitor by a neutrophil metalloproteinase. J. Clin. Invest. 81, 1646-1650. 

Zhang, Z., Winyard, P.G., Chidwick, K., Farrell, A., Pemberton, P., Carrell, KW. and Blake, D.R. (1990). Increased proteolytic cleavage of ai-antitrypsin (ai-proteinase inhibitor) in knee-joint synovial fluid from patients with rheumatoid arthritis. Biochim. Soc. Trans. 18, 898-899. 

Weissbach, H. and Brot, N. (1981). Enzymatic reduction of oxidised alpha-l-proteinase inhibitor restores biological activity. Proc. Natl Acad. Sci. USA, 78, 7483—7486. 

AP ai-antiproteinase also known as ai-antitrypsin and ai-proteinase inhibitor... 

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